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KMID : 0364219760190030113
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Korean Journal of Zoology
1976 Volume.19 No. 3 p.113 ~ p.122
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Methyl Methanesulfonate Stimulated $^3H$ 수식 이미지-Thymidine Uptake in Synchronized HeLa S3 Suspension Cells Pretreated with Thymidine Analogs
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Park Sang-Dai
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Abstract
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The rate of $^{3}H$-thymidine uptake induced by MMS in asynchronous HeLa $S_3$ suspension cells was decreased in direct proprotion to dose increase. The combined treatment of BUdR or IUdR with MMS was more effective in reducing the rate of $^{3}H$-thymidine uptake. MMS-stimulated $^{3}H$-thymidine uptake was detected in synchronized $G_2$ stage cells of HeLa $S_3$ suspension cultures following treatment with thymidine double shock. BUdR and IUdR greatly enhanced MMS-stimulated $^{3}H$-thymidine uptake. IUdR was found to be a more effective sensitizer than BUdR in this respect.
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KEYWORD
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